Lab Director Essay

J. Chem. Chem. Eng. your five (2011) 897-902

Remote Control of Fed-Batch Fermentation Systems

Richard Moreau3, Floyd Inman, III1, Sunita Singh2, Heather Walters1 and Leonard Holmes1* 1 . Biotechnology Analysis and Training Center, College or university of North Carolina at Pembroke, Pembroke, NC, USA 2 . Central Institute of Farming Engineering, Bhopal, Madhya Pradesh, India several. UniversitГ© sobre Picardie Jules Verne, Amiens, France

Received: June 14, 2011 / Accepted: This summer 11, 2011 / Posted: October 12, 2011. Subjective: Bioreactor procedure requires constant monitoring of fermentation guidelines and current control over bioreactor devices. Remote monitoring and control of the bioreactor's laptop via the Internet avoids the necessity of personnel being constantly onsite during operation. A two liter Sartorius-stedim BiostatВ® A Plus fermentation system was networked and interfaced with all the commercial software from GoToMyPCВ® to allow handy remote control of the fermentation system utilizing the internet. The fermentation vessel was furnished with hardware calibrated for monitoring and handling culture variables during experimentations. The uniform resource locator controlled night-vision web camera allowed constant monitoring in the glass fermentation vessel in the daytime and at night time. The main window screen in the laboratory computer system can be securely accessed via any lightweight device (i. e. laptop) capable of building an Internet interconnection and carrying out the commercial software by GoToMyPCВ®. The secured internet protocol talk about, provided by GoToMyPCВ®, assures which the system can easily be manipulated by certified users who have been given access to the bank account. This interface permits the remote control from the BiostatВ® A vital fermentation program and possibly other automated or perhaps potentially automated culturing devices at the comfort of the user(s). Key words: Fermentation, Fed-batch, Remote-monitoring, Remote-controlled fermentation systems.

1 ) Introduction

Fed-batch fermentations can be defined as processes

where a usable substrate is added over particular

intervals during the life with the batch to keep up

optimal base concentrations in promoting the

optimum production of the desired merchandise. At the

bottom line of the batch, the fed-batch culture can be further

prepared to detox the desired item. These

fed-batch cultures are maintained and cultured in

complex fermentation systems that monitor the

fermentation method [1]. Fed-batch fermentation

systems are extensively employed in the food and

pharmaceutical industries where they may be mainly

applied because that they merge the benefits of equally

batch and continuous fermentation processes to lessen

costs [2]. In industrial fermentation systems, regular

operations are achieved through manual control by

*

Corresponding author: Leonard Sherlock holmes, Ph. M., research

discipline: fermentation technology. E-mail: len. [email protected] edu.

process operators/technicians. These employees can

detect potential complications and help to make necessary

adjustments to the fed-batch process based upon the

knowledge of the process and the measurements

which have been provided by the fermentation application [2].

Areas that involve cellular or cells culturing may need

constant and real-time control over devices that

monitor and control diverse culturing parameters.

However , these kinds of parameters are mainly controlled

through real-time actions that usually require the

existence of clinical personnel to execute.

Modern fermentation systems are now controlled

through automation based upon software that utilizes a

computer system interface where the process agent (user)

can easily set on the web fermentation parameters (pO2, pH,

temperature, and so forth ) to get monitored and controlled by the

rider software with the fermentation program requiring

tiny oversight by the user [3]. Nevertheless , there are

more offline-parameters that cannot be

898

Remote Control of Fed-Batch Fermentation Systems

supervised or...

Recommendations: Eng. 2002, 24, 273-279.

Fed-Batch Fermentation. Biotechnol. Bioeng. 2001, 74,

125-135.

GmbH, 2009.

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